Brilliant Minds Essay Research Paper Running head

Splendid Minds Essay, Research Paper Runing caput: BRILLIANT MINDS Splendid Minds of Frank and Lillian Gilbreth Willie B. Slope, Jr. Southern Illinois University at Carbondale ________________________________________________________________ ELM-300 Introduction to Electronic Management Research Spring Semester 2000 Fortification Gordon, Georgia Contentss Page Unique # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; .3 Presentation # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; 4 Movement STUDY # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; .4 Exhaustion STUDY # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; .6 End # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; .. # 8230 ; # 8230 ; .7 REFERENCES # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; # 8230 ; .. # 8230 ; # 8230 ; .8 Reflection Plain and Lillian Gilbreth were two of the incredible pioneers of in the review of Scientific Management. Two of there significant Hagiographas were on Fatigue Study and Motion Study. Business bookmans utilize a considerable lot of their Hagiographas, today. A large number of their results influence the work conditions in numerous organizations. Splendid Minds of Frank and Lillian Gilbreth Straight to the point Gilbreth was conceived on July 7, 1868 in Fairfield, Maine. Lillian Gilbreth was conceived on June 24, 1924 in Montclair, New Jersey. The Gilbreths # 8217 ; are viewed as two of the best American bookmans in the field of logical heading. Numerous expert concern chiefs utilize huge numbers of their Hagiographas. A significant number of their Hagiographas incorporate The Psychology of Management, Fatigue Study, Motion Study for the Handicapped, Applied Motion Study, Motion Study, Primer of Scientific Management, Bricklaying System, and Concrete System. One of the incredible scholarly Hagiographas by the Gilbreths was the overview of motion. Signal overview is an organization to changeless and viable waste riddance ( Gilbreth, 1917 ) . This work is expect to portray the work nations that motion overview can be or is being applied and various techniques to use to the review. At long last, the outcome of the study. Signal study was primarily utilized in American Industry. The finish of this study was to quench unneeded endeavor utilized in the business to each piece low as could be expected under the circumstances. The improvement of an occupation undertaking while at the same time expanding productiveness was the result. The American mechanical segment was utilized in light of the fact that it was spread trip during this clasp and America expected to better modern procedures to remain competitory against different states. Signal study investigated each nitty gritty in the activity to execute an impossible to miss undertaking and decided the strategy which utilized minimal whole of vitality. A delineation of this exploration is the gathering of piece utilized in the creation of the braider fabricated by the New England Butt Company ( Gilberth 1917 ) . After examination using signal review there was a 300 and 50 for every centum expansion underway with no expansion in specialist exhaustion ( Gil breth 1917 ) . The investigation comprised of what is the unit of step, the distinction techniques utilized, and gadgets required. Each of the three are should have been consolidated to get a result. The utilization of chronocyclegraph signal gadgets was another strategy utilized in motion review. Chronocyclegraph gadgets were utilized in the study to explain an exact logical choice to a test. Timekeepers, temperature, and area gadgets was utilized during the review. This was important to procure the precise clasp of twenty-four hours, temperature, and topographic point a study was performed. The data can be notice in the great beyond or the present by researcher and bookmans to think about other logical results from motion study. The third kind used to settle on a choice in signal review was a motion hypothetical record. Signal hypothetical records were utilized mainly in instructive segment ( Spriegel 1953 ) . It managed the various techniques for guidance by a man. The diagram of the review was that various strategies are utilized to execute the endeavor than what is educated by the teacher. In one delineation, the teacher trained a person who was new to a theme an extremely exhaustive record on the best way to bring through the endeavor, which was truly cut expending ( Gilbreth 1917 ) . On the different manus, when truly executing the endeavor the instructor utilized shorts that decreased the entirety of clasp to execute the endeavor ( Gilbreth 1917 ) . One more of the Gilbreths # 8217 ; plants was an overview of exhaustion in the work environment Fatigue is the weakness from work or exertion ( Webster 1994 ) . This was intended to preeminent, to discover what kinds of business causes various sorts of exhaustion. Second, to gauge how unneeded exhaustion can be disposed of. Third, to chop down the whole of exhaustion in the work environment each piece low as could reasonably be expected. Fourth, to discover various strategies to fight exhaustion. Fifth, to set the data accumulated by the overview in a signifier that the mean laborer can comprehend. The two sorts of exhaustion are important and unneeded. Pointless exhaustion is brought about by work that utilizes more vitality to bring through an endeavor than is required or executing an occupation that ought to non be performed to make an end ( Myers 1953 ) . A decent outline of slothful vitality is crafted by the bricklayer. The technique for a considerable length of time was for the bricklayer to raise his natural structure, the howitzer, and the blocks from the land to the highest point of the building ( Gilbreth 1916 ) . This kind of work utilized a major aggregate of unneeded vitality. Vital exhaustion is brought about by the accomplishment of any endeavor. For delineation, there may be an advancement to a work strategy, which brought about an expansion of productiveness by 50 for each centum. Despite the fact that more work was practiced in a similar aggregate of clasp it did non or can be relied upon to quench all exhaustion. One of the most strong approaches to chop down exhaustion is to better the workplace of a representative. The business needs to ensure a laborer has sufficient clasp to rest and pass cut with the family unit at the terminal of the twenty-four hours. One of the approaches to ensure a worker is non depleted is to gracefully a lunch period and at any rate one twenty-four hours a hebdomad off from work. Another technique is to ensure the best possible gear is utilized to execute an endeavor. The Gilbreths # 8217 ; did a study, in which, they gave a lean sponsorship seat to all specialists in an organization. After one hebdomad of utilization the organization expansion productiveness with less specialist exhaustion ( Spriegel 1953 ) . Legitimate lighting in the work environment is another way to chop down exhaustion. In the event that a working environment has unnecessarily a lot or non bounty illuming the laborers will tire at a more noteworthy rate since it will do constant settlement and re-change of the eyes. Choice Improvement of working conditions is essential to expanding laborer productiveness. The Gilbreths # 8217 ; committed their lives to think up techniques to chop down specialist exhaustion and misuse of unneeded vitality. A significant number of their contemplations are joined to numerous Torahs passed by the specialists during the 1930s # 8217 ; and 1940s # 8217 ; . Disappointment of worries to keep the principles of the Gilbreths # 8217 ; could result in lower specialist productiveness and spirit. An of import fixing in an organization # 8217 ; s productivity is a decent connection with bearing and the worker. Book reference Notices Gilbreth, F. , A ; Gilbreth L. ( 1916 ) . Weariness Study. New York: Sturgis A ; Walton Co. Gilbreth, F. , A ; Gilbreth L. ( 1911 ) . Motion Study. New York: D. Van Nostrand Co. Merriam-Webster # 8217 ; s School Dictionary ( 1994 ) . Springfield, MA: Merriam-Webster Inc. Meyers, C. E. , Spriegel W. R. ( Eds. ) . ( 1953 ) The Writings of the Gilbreths. Homewood, Illinois: Richard D. Irwin, Inc.

F. Scott Fitzgeralds The Great Gatsby Essay -- English Literature Ame

The Great Gatsby The fundamental topic of the novel â€Å"The Great Gatsby† centers around the American Dream and it is depicted through the term of Jay Gatsby. Through Gatsby’s life we see the shrinking of the American Dream, a disaster that struck Jay’s close to completed dream. The American Dream is the thing that many have trusted of accomplishing, it has existed before and is in the present. The American Dream gives individuals an objective that they can progress in the direction of, it additionally gives them a reason throughout everyday life. The American Dream speaks to extravagance and riches it accepts the decency of the personal satisfaction. For Jay Gatsby, he was so near accomplishing the American Dream. He had the riches and the class, all he required was his tragically deceased love, Daisy. Gatsby really accepted that he could indeed be along with Daisy we see this when he says Can't rehash the past? he cried warily. Why obviously you can (P. 116). Anyway what made the story such a catastrophe was, that Gatsby verged on wining Daisy anyway he was executed by Mr. Wilson which he was simply inches from effectively finishing the American Dream. Before, just a modest quantity of the American Dream ended up being fruitful, most have fizzled. Numerous individuals who didn't accomplish the American Dream wound up ending it all or different methods for abandoning life since they accept there was no other reason throughout everyday life. Gatsby speak to the American Dream from numerous points of view, so as to achieve his Dream he knew precisely what he wanted, when Jay met Dan Cody at the shore of Lake Superior, Dan indicated him a dream of progress a dream of what riches would offer, the fervor of being rich. Jay Gatsby has a driven nature, there for he would do anything just to live the American Dream. He began by building a past, he changed his name from James Gatz to Jay Gatsby trying to develop an establishment for his fantasy. He at that point made a picture for Jay Gatsby, a well honorable man who was conceived in the west, instructed at oxford and battled in World War I. Gatsby was then ready to accomplish a lot of cash working with Meyer Wolfsheim. He at that point purchased an immense manor in the â€Å"West Egg†, anyway he would toss indulgent gatherings in trusting of pulling in his tragically deceased love Daisy, the person who he had an unsanctioned romance with before he went to the war. Scratc h depicts Gatsby’s sentiments about Daisy: He hadn't once stopped taking a gander at Daisy and I think t... ...d him Michaelis saw with a stun that he was taking a gander at the eyes of Doctor T. J. Eckleburg which had quite recently developed pale and huge from the dissolving night (P. 167) He accepted that god would legitimize his activities since god is viewing through the eyes of Dr. Eckleberg. So he shot Jay Gatsby whom he thought Myrtle was taking part in an extramarital entanglements with, at that point he shot himself.      All things stated, I think the desire for the American Dream is more than difficult to accomplish. Not every person can locate that ideal perfect partner and not every person can remain well off for an extensive stretch. Particularly during this progressive century, cash is effectively earned yet in addition handily lost. I think for some individuals the American Dream is a reason forever, a troublesome objective for aspiring individuals like Gatsby to reach. Actually, I don't accept this, I accept that we should carry on with a fair life, so our entire life is even. Not at all like how a few people work 75% of their life to appreciate that one quarter life of the American Dream. At long last you will lose every one of your companions and maybe even your life on the off chance that you don’t succeed. To me the lesson of the book implied make an amazing most while it keeps going, you just have such a great amount of time to appreciate it.

Value Essay Samples

Value Essay SamplesValue essays are the soul of all good essays. They should be written and delivered with a certain purpose in mind. In this regard, many essay writers believe that the purpose of the essay is to present information to the reader in such a way that it makes the recipient see the reader as more knowledgeable than the reader himself. More often than not, this essay is perceived to be a test of literary ability that the reader must pass to get the attention of the writer.On the other hand, there are essay samples that allow the writer to go for the perfect reflection of his own thinking on the matter at hand. Essay samples like this make the essay look less like a test and more like a reflection of the author's own emotions, thoughts, and feelings.Essays with feelings should be taken with a grain of salt. In a sense, we can call this one-sidedness of expression, for the ideas and opinions conveyed in the essays are expressed in such a way that the writer is making the r eader 'feel' for the material rather than giving the reader 'seeing' the material.We can speak of how essays with too much emotion will take up too much time and in the end, will seem as if they were 'worth reading' only for its ability to convey feelings. In other words, it will make a reader feel the point it is trying to make.However, we should also think of how these essays are written to try and 'give' a person 'seeing'getting' of what the essay is trying to say. This is when the writer finds himself conveying more than just an emotion. Thus, it is said that emotions should not be allowed to rule the writing of essays.But this does not mean that value essay samples are not allowed to express themselves. It only means that they should be guided by something else. The point is that these examples, no matter how great they are, do not have the ability to express emotions and thoughts.In truth, the more opinions vary on this, the more it becomes impossible to be written about. Essa ys can be used to express certain things, but should not be allowed to overdo it, because even if they express themselves well, they cannot really tell anyone what their own personal thoughts are.When writing value essay samples, the reader should take note of how the writer expresses his views and ideas in the way he feels. This way, he will have an idea about what the essay was really trying to state or portray.

Crystal Meth/Methamphetamine Information

There are several different types of amphetamines, which are stimulants. Crystal methamphetamine or simply crystal meth is an illegal form of the drug. Heres what you need to know. What Is Crystal Meth? The chemical n-methyl-1-phenyl-propan-2-amine is called methamphetamine, methylamphetamine, or desoxyephedrine. The shortened name is simply meth. When it is in its crystalline form, the drug is called crystal meth, ice, Tina, or glass. See the table below for other street names of the drug. Methamphetamine is a highly addictive stimulant. How Is Crystal Meth Used? Usually, crystal meth is smoked in glass pipes, similar to how crack cocaine is used. It may be injected (either dry or dissolved in water), snorted, swallowed, or inserted into the anus or urethra. Why Is Crystal Meth Used? Females often take crystal meth because it can cause extremely rapid weight loss. However, the effects are short term. The body builds up a tolerance to the drug so weight loss tapers off and stops around six weeks after taking the drug. Also, the weight that is lost is regained once a person stops taking methamphetamine. For these reasons, combined with how addictive the drug is, methamphetamine tends not to be prescribed by doctors for weight loss. Some people take meth because of the long-lasting high that it gives. Methamphetamine causes numerous neurotransmitters to be released in the brain, producing a sense of euphoria that may last as long as 12 hours, depending on how the drug was taken. Methamphetamine is popular as a stimulant. As a stimulant, methamphetamine improves concentration, energy, and alertness while decreasing appetite and fatigue. Methamphetamines are also taken by people who are feeling depressed. They may be taken for their side effect of increasing libido and sexual pleasure. What Are the Effects of Methamphetamine Use? This is a list of effects associated with pure methamphetamine use. Because of how its made, crystal meth is never pure, so the dangers associated with taking the street drug extend beyond these effects. Common Immediate Effects EuphoriaIncreased energy and alertnessDiarrhea and nauseaExcessive sweatingLoss of appetite, insomnia, tremors, jaw-clenchingAgitation, irritability, talkativeness, panic, compulsive fascination with repetitive tasks, violence, confusionIncreased libidoIncreased blood pressure, body temperature, heart rate, blood sugar levels, bronchodilationConstriction of the walls of the arteriesIn pregnant and nursing women, methamphetamine crosses the placenta and is secreted in breast milk Effects Associated With Chronic Use Tolerance (needing more of the drug to get the same effect)Drug cravingTemporary weight lossWithdrawal symptoms including depression and anhedoniaMeth Mouth where teeth rapidly decay and fall outDrug-related psychosis (may last for months or years after drug use is discontinued) Effects of Overdose Brain damageSensation of flesh crawling (formication)Paranoia, hallucinations, delusions, tension headacheMuscle breakdown (rhabdomyolysis) which can lead to kidney damage or failureDeath due to stroke, cardiac arrest or elevated body temperature (hyperthermia) Physical and Chemical Properties of Crystal Meth Crystal meth may be distinguished from other drugs and compounds by its properties. The compound forms two enantiomers (compounds which are mirror images of each other), dextromethamphetamine and levomethamphetamine.Methamphetamine hydrochloride salt is a white crystal or crystalline powder at room temperature that is bitter-tasting and odorless, with a melting point  between 170 to 175  Ã‚ °C (338 to 347  Ã‚ °F). It readily dissolves in water and ethanol.The free base of methamphetamine is a clear liquid that smells like geranium leaves. It dissolves in ethanol or diethyl ether and mixes with chloroform.Although crystal meth is a persistent pollutant in soils, it is degraded by bleach or within 30 days in wastewater that is exposed to light. Where Does Crystal Meth Come From? Methamphetamine is available with a prescription for obesity, attention deficit hyperactivity disorder, and narcolepsy, but crystal meth is a street drug, made in illegal labs by chemically altering over-the-counter drugs. Making crystal meth usually involves reducing ephedrine or pseudoephedrine, found in cold and allergy medicine. In the US, a typical meth lab employs something called the Red, White, and Blue Process, which entails hydrogenation of the hydroxyl group on the ephedrine or pseudoephedrine molecule. The red is red phosphorus, white is the ephedrine or pseudoephedrine, and blue is iodine, used to make hydroiodic acid. Making crystal meth is dangerous to the people making it and dangerous to the neighborhood where its being made. White phosphorus with sodium hydroxide can produce poisonous phosphine gas, usually as a result of overheating red phosphorus, plus white phosphorus can auto ignite and blow up the meth lab. In addition to phosphine and phosphorus, various hazar dous vapors may be associated with a meth lab, such as chloroform, ether, acetone, ammonia, hydrochloric acid, methylamine, iodine, hydroiodic acid, lithium or sodium, mercury, and hydrogen gas. Street Names for Crystal Meth Crystal meth goes by a number of names: BatuBikers CoffeeBlack BeautiesBladeChalkChicken FeedCrankCristyCrystalCrystal GlassCrystal MethGlassGo-FastHanyakHiroponHot IceIceKaksonjaeL.A. GlassL.A. IceMethMethlies QuickPoor Mans CocaineQuartzShabuShardsSpeedStove TopSuper IceTinaTrashTweakUppersVentanaVidrioYabaYellow Bam

Thailand National Profile History and Culture

Comparing The Flea By John Donne And To His Coy Mistress

Love Me, Love Me Not The two poetics from whom have created pieces of literature in the past such as â€Å"The Flea† by John Donne and â€Å"To His Coy Mistress† by Andrew Marvell, whom were highly educated poets in the 17th century, in which their writing styles were pieces of unique abstract, theoretical forms, and one particular famous style called metaphysical conceit to which â€Å"John is known as the founder of the HYPERLINK https://www.poets.org/poetsorg/text/brief-guide-metaphysical-poets Metaphysical Poets, a term created by Samuel Johnson, an eighteenth-century English essayist, poet, and philosopher†(JOHN). In both poems â€Å"The Flea† by John Donne and â€Å"To His Coy Mistress† by Andrew Marvell is that they both used imagery to underline the†¦show more content†¦The words in the poem that surround what will happen if they don’t have sex are that she will be eaten by the worms and they will ultimately try to take her â€Å"virginityâ₠¬  while he holds the idea of her remaining a virgin forever in disdain, but on the other hand there will be repercussions for him as well, in the sense that all his sexual fantasies, desires, and wants will burn up, â€Å"And into ashes my lust† (Line 30). In the poem â€Å"The Flea† by John Donne has powerful imagery in it as well, such as the blood representing life experiences in and of itself, but in the story when it says â€Å"It sucked me first, and now sucks thee, /And in this flea our two bloods mingled be;† is basically telling us that a flea had bitten and drawn blood from the male and female and that these two bloods have intermingled, so in the speakers convincing argument to the woman was that their bloods are intermingled, thus persuading the woman that they are as one now as the poem states â€Å"This flea is you and I, and this/Our marriage bed†(Lines12-13) and should become sexually involved with each other since they are â€Å"marrie d† within the flea. Therefore, the two poems contain vivid sexually charged imagery. In the poem â€Å"To His Coy Mistress† by AndrewShow MoreRelatedMetaphysical Poems792 Words   |  4 PagesMetaphysical Poets John Donne and Andrew Marvell were considered metaphysical poets based on their use of conceit and wit in depicting similar situations through different metaphors. They would use original analogies to create fitting and insightful comparisons, usually to persuade. John Donne and Andrew Marvell have been called metaphysical poets. This is a,† name given to a group of English lyric poets of the 17th century† (Metaphysical poets)† The term metaphysical poets came to be used almostRead MoreThe Flea By John Donne And His Coy Mistress By Andrew Marvell1059 Words   |  5 Pagespoets like John Donne and Andrew Marvell who participated in a type of poetry referred to as metaphysical. Metaphysical poetry essentially is poetry that deals with things that are more philosophical than anything else. This type of poetry also is very emotion based but also has logically aspects. These poets have written several bodies of work that can fall under the metaphysical umbrella. Two examples of metaphysical poems written by these two poets are The Flea and To His Coy Mistress. Being metaphysicalRead More The Poetry of Andrew Marvell and John Donne Essay951 Words   |  4 PagesThe Poetry of Andrew Marvell and John Donne The seventeenth century was an era of beautiful poetry. Two poets in particular, Andrew Marvell and John Donne, wrote carpe diem poetry full of vivid imagery and metaphysical conceits. Each conveyed the message of living for the now. This message can be clearly seen in the poems To his Coy Mistress by Marvell and Donne’s Flea. By using clever metaphors and meter, the poems not only are symbolic, but have almost a physical aspect to them. ThoughRead MoreComparison of how The Flea and To His Coy Mistress Present and Develop the Poets Arguments2031 Words   |  9 PagesThe Flea and To His Coy Mistress are two poems written by poets living during the Renaissance Period. To His Coy Mistress was written by Andrew Marvell and The Flea was written by John Donne. Both of these poets were well-educated metaphysical poets, and these poems illustrate metaphysical concerns, highly abstract and theoretical ideas, that the poets would have been interested in. Both poems are based around the same idea of trying to reason with a mistress as to why they should give up theirRead MoreCharacteristics of Metaphysical Poetry876 Words   |  4 Pagesthe formal structure (of rhyme, metre and stanza) is the underlying (and often hardly less formal) structure of the poem s argument. Note that there may be two (or more) kinds of argument in a poem. In To His Coy Mistress the explicit argument (Marvell s request that the coy lady yield to his passion) is a stalking horse for the more serious argument about the transitoriness of pleasure. The outward levity conceals (barely) a deep seriousness of intent. You would be able to show how this theme ofRead More Love in The Flea and To his Coy Mistress Essay2087 Words   |  9 PagesLove in The Flea and To his Coy Mistress Compare the ways John Donne in his poem The Flea and Andrew Marvell in his poem To his Coy Mistress present the theme of love. Donne and Marvell’s poems have both similarities and differences, as they both present the theme of love in an unconventional way and dwell on it superficially. This can be seen by the way in which both authors show their views on love, though are clearly just using them as attempts to seduce their mistresses, who are clearlyRead More Love in To His Coy Mistress, Shall I Compare Thee, Let Me Not, and The Flea3166 Words   |  13 Pagesin To His Coy Mistress, Shall I Compare Thee, Let Me Not, and The Flea The four poems I am going to be comparing are, â€Å"To His Coy Mistress,† â€Å"Shall I Compare Thee,† â€Å"Let Me Not,† and â€Å"The Flea.† All four of these poems are based on the subject matter of love. The four poems have a lot in common but each poem touches a different aspect of love. Two of the poems, â€Å"Shall I Compare Thee†, and â€Å"Let Me Not†, are sonnets and both were written by Shakespeare. â€Å"To His Coy Mistress† is writtenRead More Persuasive Techniques Used in Poetry Essay2193 Words   |  9 Pagesin a way to signify the fast approach of the virgins death. He uses the phrase â€Å"smiles today†, to tell us that beauty goes quickly and it will soon ware out so you must use your time while you have your beauty. Herrick uses phrases such as â€Å"his race be run† and â€Å"Nearer he’s to setting†. These are also to express the running out of time with speed. In the first stanza, the first two lines have a positive disposition and in the third and fourth lines the form changes to a negativeRead More The Flea by John Donne and To His Coy Mistress by Andrew Marvell6621 Words   |  27 PagesThe Flea by John Donne and To His Coy Mistress by Andrew Marvell The Flea by John Donne is written in the 17th century as is To his coy mistress by Andrew Marvell. This we can see by the language used which was typical of that period in time apt to kill me and yea which are taken from the flea. Both poems also speak of virginity being very important, especially before marriage because if a woman had lost her maidenhead before, the husband would have the right to leave her withoutRead MoreMetaphysical Poetry By John Donne1590 Words   |  7 Pageswho wrote his book which is known as ‘’Lives of the Most Eminent English Poets’’, Henry Vaughan, Andrew Marvel, Richard Crashaw, George Herbert and finally who was the main founder, John Donne. John Donne (1572 - 1631), the founder of the Metaphysical school of poetry, lived and wrote during the succeeding reigns of Elizabeth I, James 1 and Charles I. His early life was passed in dissipation and roguery, much occupied with secret love-making, elopement, imprisonment, and lawsuit over his marriage

Management Discussion and Analysis

Question: Discuss about the Management Discussion and Analysis. Answer: Management discussion and analysis (MDA) is a section of a business annual report in which an overview of previous year operations and business performance is provided. MDA plays an important role for financial analyst as it helps him to figure out all the information of financial condition of an organization. It uses by analyst to provide information to clients. It helps analyst to enhance the financial disclosure and provide the financial information. It is required to understand the financial condition and operations result. An analyst helps investors using MDA to look into the company through managements eye by providing them companys financial statement. A context is provided to analyst by using MAA approach to reach into a conclusion. It helps analyst to getting the information about the quality and potential variability of a companys financial detail like cash flow and companys earnings. It also helps an investor to ascertain that past performance indicative to future. MDA hel ps the financial analyst to give the narrative explanations of the financial statement of a company (US Security exchange, 2003). With the help of it, financial analyst can improve overall disclosures provided by him for investors and company as well. It helps analyst to check each and every thing related to financial condition like annual reports, companys liquidity, capital expenditure etc. It helps analyst to identify the change in fair value attributes to change in value technique. It helps an analyst to indicate the maturity of current balance sheet based on either estimated price or fair value (Friedlob Schleifer, 2003). References Friedlob, G. Schleifer, L (2003). Essentials of Financial Analysis. US: John Wiley Sons. US Security exchange (2003). Commission Guidance Regarding Management's Discussion and Analysis of Financial Condition and Results of Operations. Retrieved on 14 November 2016 from https://www.sec.gov/rules/interp/33-8350.htm.

Distributed Computing Essays (1426 words) - Distributed.net

Distributed Computing Distributed Computing Chapter 1 As the technology we use today increases in speed and usability, there are those that are happy with the fastest computer. But then there are those that either want or need to go faster than the fastest. The solution lies in and around the Internet, the solution has been rightfully termed Distributed Computing. Put simply, distributed computing is the splitting of a task among multiple computers. Hence using the power of many computers that people already have, thus sparing the cost of buying a supercomputer of equal proportions, which in some cases is impossible. Distributed Computing isn't all that hard of a concept to grasp. The first thing that would be done when setting up a distributed computing operation is the selection of the problem that you to tackle. This allows you to decide what the basic architecture of the network is going to be. To help describe the process better, I will step through the process of setting up an imaginary distributed computing project. I am bored one day, and surfing the web, and I run into RSA's homepage, were they had just announced a new competition in which they have put up an offer to give ten thousand dollars to the person that successfully cracks any one of their encryption standards under the RC5 brand. You know that RC5-56 has been cracked, and RC5-64 is being cracked using brute force distributed computing. So you decide to take on RSA most secure encryption standard, tackling the challenge to take on RC5-128, officially called RC5-32/12/16. Tackling this problem with brute force is probably the easiest method, but this cipher is 2^64 times stronger than RC5-64, so we are going to need quite the backing for this. Seeing how money is only a slight problem, we go out and buy a web server, a key server, and a so-called stats server. We also buy a copy Visual Studios 6.0, (for coding the clients). I introduced some possibly foreign terms in the last paragraph, so let me explain. A key server is possibly the most important part of a distributed computing project. Its only purpose is to keep the clients supplied with blocks of keys. The stats server being a part of the network that isn't critical to the project, but to get the amount of people we will need to crack this code, we want to make sure their happy, and geeks love stats. The client is a program that runs on a workstation, in our case, it will be testing a key against the encrypted message that was supplied to us by RSA, for this project, the encrypted message is: d9 3b 27 72 11 8a 65 cb ef 5b 06 74 63 76 22 16 84 f9 ec 21 56 3b 1c 1c 02 e1 70 10 50 d1 71 00 06 aa bf c1 38 e1 f1 f8 2d 63 57 bb 24 a9 7d 5d All the client needs to know is the first line or so, this is for speed issues, as it takes less time to test against one line, than it does to test against three, if the client thinks it has a possible code, it will put a flag on that key and send it back to the key server, which sees the flag, and tests the key against the rest of message, if it works, we send it off to RSA, and they make it official and send us our check. To reduce the load on the key server we send the keys over the internet in blocks, with somewhere between 2^34 and 2^64 keys, the bigger blocks containing 1,844,674,407,000,000,000 keys, roughly .000000003 percent of the total 33,402,823,669,000,000,000,000,000,000,000,000,000 keys, just to give you an idea of how big of a project this is. We send the keys over the Internet for the simple reason that we need lots of people and the Internet provides the perfect medium for communicating with all these people. So, we have all the hardware we need to take on this project, and now we have to code the client. We follow all basic procedures in making any program, including beta testing. After the client is ready to be released, we start

David M Buss essays

David M Buss essays His main area of study has been human desires, what people want when they are looking for a husband or wife. To research this, he surveyed over ten thousand people in thirty-seven cultures on six continents. What his findings show is that men tend to choose mates more on physical attractiveness and youth. While women seek men with more financial power. Now this may come as no surprise to us in America, because men here have always wanted women who were more physically attractive, and women have always wanted to marry a rich man, like a doctor or a lawyer. What Buss found out is that it is also similar in other cultures. How a mans wealth is determined may vary, but the mans desirability is the same. From his studies and what he has gathered from past information, he has put together a good theory that explains why we have our preferences for a mate the way we do. It dates back to our ancestors, some of the first humans. The main goal for them was to survive. To do this men wanted to have as many children as they could. Women wanted men who could protect them. For them the mans wealth was measured by his social status, strength, and ability to fight (to protect themselves). From generation to generation these traits were inherited, written deep down in our subconscious. The characteristics men look for in women are: skin tone, symmetry in the face, clear skin (acne can be a pre-indicator of high testosterone levels, which could mean they may have ovarian dysfunction), and a low hip-to-waist ratio. This ratio is the 36-24-36 measurements. This certain hip to waist ratio is a strong indicator that the woman is more fertile, and thus able to have more children. The reason men want younger women as their choice for mates is that because theyre younger, once again they can produce more children. Of course now theyre not as interested in having a large family, but the ...

History 2 Essay Example | Topics and Well Written Essays - 1000 words

History 2 - Essay Example As in earlier novels, Grass uses Crabwalk to ask whether subsequent generations of German citizens have adequately dealt with the horrors of the Third Reich. The nation's policy of remorse does not provide the analysis and the assumption of personal responsibility which Grass thinks is necessary. In the deftly-woven plot of Crabwalk, shortsightedness and regret characterize modern Germany, but this vision is far more bleak than the reality. This essay will look at the protagonist Paul Pokriefke – namely his relationships with his mother and son – as well as the significance of the sinking of the MV Wilhelm Gustloff. Germany's reaction to its past is an issue which has not been left dormant over the seventy years since the war. The Reader, written by Bernhard Schlink in 1995 and made into a film in 2008, is just one other of the Vergangenheitsbewaltigung genre, in which German writers struggle to come to terms with their collective past. The problem to be resolved is tha t different factions of society obviously have different solutions for how to deal with the repercussions of the Third Reich. ... The first step of this process is portrayed in Tulla's relationship with her son. Paul refuses to believe his mother's statement that she went into labor with him when the ship MV Wilhelm Gustloff began to sink, attributing this to her sense of drama rather than actual fact. The repercussions of Paul's secret disbelief of his mother will be discussed below. In general terms, Tulla's demand of Paul that he write a history of the capsizing reflects her generation's incapability to deal with Nazism, and the way this responsibility was handed off to a generation who felt equally as unable, as well as far less culpable. In The Reader, Bernhard Schlink expresses the reaction of the second generation as a complete laying of the blame on the silent parents, regardless of whether they had actually been personally involved in the Nazi regime. This approach is just as untenable and unfair as Grass's insistence that the blame should be taken on the shoulders of subsequent generations. Paul's rel ationship with his mother portrays the uneasy dysfunction between those who lived through Nazism and those who came immediately after it. Tulla's silence, coupled with her wish that her son break that silence for her, creates an unhappy family and an unhappy country. This silence, borne of shame, means that following generations will not fully understand the evil of Nazism – the oft-repeated and almost clicheic statement that â€Å"those who forget the past are condemned to repeat it† (George Santayana) is wholly appropriate in the case of Konrad. Grass's antagonist is Konrad Pokriefke, Paul's estranged son, whose close relationship with his

Readers response Essay Example | Topics and Well Written Essays - 500 words

Readers response - Essay Example Finally, the plotline has almost nothing to do with a love story. Faulkner introduces Miss Emily Grierson as a woman who has never been provided an opportunity to become comfortable or familiar with the world outside of her father’s old world ideals. This created a situation in which Miss Emily â€Å"got to be thirty and was still single† (437), forced to live in her maidenhood forever and lacking any connection to the rest of the world. Her inability to relate to the real world outside her fantasy is seen when she refuses to acknowledge her father’s death. This reaction was considered strange and unusual by the people of the town who are narrating the tale, but justified by the way in which she’d been treated by this man. But this strangeness was forgotten when Emily started behaving like normal by dating Homer Barron and her retreat back into her house after he left seems understandable. The final revelation that she had killed Homer Barron and then slept with the dead corpse for years is surprising, but not out of ch aracter. The idea that this old lady slept with the decaying corpse of the lover she’d killed is really gruesome but makes a lot of sense at the same time. It seems unnecessary to explain why the story seems very gruesome. However, it also makes sense as the old people of the antebellum South continued to have troubles adjusting to the changing rules of society. Miss Emily was forced to become an old maid because there weren’t any more families of the ‘old ways’ that were close enough to her family’s old social position. By the time her father died, she was incapable of accepting any kind of change like a lot of people of the Old South were. She tried to break the mold a little bit when she started dating Homer Barron. He was a northerner and someone of a much lower social class than what

The history and spread of probation in America

The history and spread of probation in America The term probation comes from the Latin verb probare, meaning to prove or to test. Throughout history probation has been used in various forms. From its earliest American origins probation has broadened and expanded immensely in its function within the criminal justice system. The terms and conditions of probation continue to evolve, as well as the various consequences imposed if said conditions are not closely adhered to. Probation is a privilege granted to particular law violators in lieu of imprisonment. Just as the root word derived from, probation is a test issued to an offender, offering them a chance to prove themselves. HISTORY Elements of probation can be seen throughout history. There is reference in Mosaic Law to the right of sanctuary. Right of sanctuary offered cities of refuge to killers seeking to escape retribution. While probation as we know it today is not an escape from punishment, it can be seen as a sort of sanctuary in that probationers are offered the opportunity to atone for their crimes and maintain in the free society. The suspended sentence, commonly used in the Middle Ages in England, mirrors probation in that it can be revoked and a prison sentence imposed if the offender fails to stay out of trouble for the amount of time specified. Suspended sentence at this time, however, did not include any kind of supervision, nor were there any set goals of reform. There was also a form of temporary release used by the courts during this time. Binding over for good behavior offered offenders an opportunity to secure pardons or lesser sentences. Matthew Davenport Hill was a English barrister and judge in Eighteenth Century England. As Recorder of Birmingham, a judicial post, he instituted a practice for individuals who did not appear to be hopeless cases. In witnessing the sentencing of youthful offenders to the custody of their parents for supervision, Hill decided that those offenders who showed hope of rehabilitation could also be placed in the hands of willing guardians. As part of this arrangement these willing guardians would receive periodic visits from local police to stay current on the progress of the released offender. JOHN AUGUSTUS John Augustus, credited as the Father of Probation, embarked upon a journey that would revolutionize the field of corrections in America. His efforts began when he persuaded a local court in Massachusetts to release into his custody an adult drunk, instead of imprisoning him. This challenge was met with great success. A shoe cobbler in Boston, Augustus supervised the man, paid his fines, and helped him achieve sobriety. His efforts broadened to and he began taking responsibility for juveniles. Again his efforts were fruitful and the court was pleased with his results. Reform became a true possibility. Over the course of his eighteen years as a volunteer probation officer [1841-1858], Augustus bailed 1,946 men, women and children. A mere ten of this number forfeited their bond. The first probation statute was passed in 1878 shortly after his death. Augustus work was a remarkable accomplishment when measured against any standard. (New York City Department of Probation) THE SPREAD OF PROBATION By 1900, Vermont, Rhode Island, New Jersey, New York, Minnesota, and Illinois passed probation laws; by 1910, 32 more states had passed legislation establishing juvenile probation; and by 1930 juvenile probation was legislated in every state except Wyoming. (Office of Probation and Correctional Alternatives) Every state in the country offers probation to both adults and juveniles today. While the structure may vary from state to state the possibility for reform remains a strong and solid objective. Probation not only offers the offender incentive to change it saves the public enormous funds as the cost is minimal when compared to the increasing costs of incarceration. Probation also serves to abate the current concerns of overcrowding in prisons. THE USES/GOAL OF PROBATION Probation has many practical functions in the field of corrections. As mentioned above, probation is privilege not a right. One of the many aims of probation is protecting the public. Probation is generally issued to low risk, non-violent offenders. Often these offenders are open to the idea of treatment and rehabilitation in an effort to avoid becoming professional offenders. Until recently, probation was predominantly used for first offense misdemeanants, however, with the implementation of get tough laws and the war on drugs saw the court system becoming more and more bogged down with cases and the prison system became increasingly prone to overcrowding. Depending on the sentencing guidelines for the crime committed, the accused may offer to plead guilty to a lesser charge. Probation is a valuable tool for the offender, the district attorney, and the court system. If the criteria of a case make the offender eligible for probation a presentence investigation report is ordered to determine if probation could be a valid and effective punishment. The presentence investigation report includes the offenders background and their disposition to their charges as well as other useful information. CONDITIONS OF PROBATION/INTERMEDIATE SANCTIONS If probation is granted, several conditions may be imposed. These conditions will be specifically designed to the individual based on their criminal record and the nature of the crime they have pled guilty to. There are various levels of probation. The lowest level of probation is unsupervised. This is when the offender is placed on probation and perhaps ordered to pay fines and court costs but is not obligated to a regular interaction with a probation officer. They are generally ordered to call in on arranged dates and update the probation officer as to their progress as well as maintain gainful employment in the community. Supervised Probation requires the offender to report to their local probation office on an established number of days per week or month, depending on the level of supervision. Often supervised probation will contain conditions such as: reporting regularly, failing to engage in any further criminal activity, submitting to searches, abstaining from using drugs, abstaining from owning a firearm, limiting alcohol intake, abstaining from associating with known criminals and notifying their supervising officer of any major changes such as relocation or job change. (Allen, Latessa, and Ponder 93) The probationer is required to pay a monthly supervision fee and a schedule to pay other fines and court fees imposed is set up between the offender and the probation officer. Certain individuals have specific conditions of probation to which they must adhere. This is sometimes as a result of the crime they committed (including factors of the crime, such as drug abuse). Specific conditions include (but are not limited to): methadone maintenance, taking Antibuse, attending 12-Step meetings, drug testing, treatment (inpatient or outpatient), and vocational training. (Allen, Latessa, and Ponder 93) These conditions are imposed to aid the probationer in successful completion of their court ordered term of supervision. There has been an adequate success rate with these programs to date. Special conditions of probation are additional punishments ordered by the courts and act to strengthen supervision. The goal is to reduce recidivism by addressing the underlying cause of the individuals criminal behavior as well as protect the local community. Special conditions of probation are: house arrest, electronic monitoring, intensive supervision, halfway house residency, boot camp programs and split sentences. (Allen, Latessa, and Ponder 93) Imposing these special conditions is at times the last line of defense for keeping the offender out of prison. In some cases, if probation is violated, additional conditions can be imposed in an effort to get the offender back on track. REVOCATION OF PROBATION Failure to adhere to these conditions, excessive violations of these conditions or failing to remain current on court mandated payments can result in probation revocation. When an offender is sentenced to a specific amount of time in jail or prison, that sentence is sometimes suspended in favor of placing the individual on probation. Repetitive violations or new charges can be cause to revoke that probation and resentence the offender or activate the sentence that they are currently on probation to avoid serving. There are a variety of reasons offenders are unable to comply with the conditions of their probation. Some are indifferent or hostile, being unwilling or unable to cooperate with their supervising officer or the court. Some are too immature emotionally to comply with directions. (Allen, Latessa, and Ponder 93) Technical probation violations require the offender to re-appear in court in front of the judge. If the probationer fails to appear a warrant will be issued for their arrest. Revocation is a serious matter and the probationer has the right to counsel for the hearing. SUMMARY The use of probation in our nations criminal justice system is widespread. Probation allows the offender the freedom to earn a living and support their family, it allows the community to feel safer knowing that these individuals are under close supervision, it saves the state money that could better be spent on reform rather than incarceration and the building of new prisons. The number of Americans currently on probation is astounding. According to the United Stated Department of Justice at the end of 2008 there were better than 4.2 million adults on probation and another almost 830,000 on parole. That number indicates that 1 in 45 adults in the U.S. is currently under community supervision. These figures show the importance of probation in America today.

Essay --

When Osama Bin Laden was killed by US Navy Seals in May 2011, strategists of the world took notice . While this incident was of great importance to an apparently stagnant global war on terror, the fact that the mastermind behind the insurgent juggernaut al Qa’ida was able to hide inside a supposed ally’s borders is of far graver concern. Regardless if Pakistan was complicit in or ignorant of Bin Laden’s sanctuary, Pakistan proved they are incapable of policing their borders to a level that satisfies the world community. US intelligence officials estimate Pakistan has anywhere from 110-200 nuclear weapons . According to George Tenet, â€Å"the most senior leaders of al Qa'ida are still singularly focused on acquiring WMD [weapons of mass destruction].† Allowing an insurgency with nuclear ambitions to flourish is inexcusable. As the war in Afghanistan winds down, the insurgent threat in the region is not going away. Irregular conflict will continue a nd the area where the US and its allies need to pay particular attention is Pakistan. Our strategy should be a globally unified effort to strengthen the Pakistani security structure while removing any potential source of an insurgency. To combat the likely difficulties in implementing this strategy we must focus on not limiting our strategic goals, embrace unity of effort as the only means to winning, and we must remain flexible in an unknown future. There are a number of obstacles that threaten to make implementing such a strategy either ineffective or impossible. Professor Colin Gray from the Centre for Security Studies at the University of Hull discussed such sources of difficulty in 1999. He argued three reasons as to why it is â€Å"difficult to do strategy well:† First, its very na... ...ture is to accept that it is unknown, and focus the unified effort on the worst possible scenario. In the case of Pakistan, that worst case scenario is obvious: insurgents getting a WMD. This nuclear threat might be the catalyst that drives competing agencies to look beyond their differences towards a very clear and common goal. Gray concludes his article with this reminder to future strategists: â€Å"You do not have to win elegantly; you just have to win.† If our strategists remained focused on â€Å"winning† we can hopefully hinder the inevitable difficulties in doing strategy well. If we do not let the difficulty of such a lofty goal limit our strategic goals, if we use the dire consequences of failure to force competent unity of effort and we don’t let an unknown future distract us from the primary goal, it is entirely possible that we can indeed â€Å"win† in Pakistan.

Pervasis Case Study

Pervasis Receives Orphan Drug Designation in Europe for Vascugel ® to Prevent Arteriovenous Access Failure in Patients Undergoing Hemodialysis Cell-Based Therapy Aims to Regulate the Body’s Healing Response, Promoting Vascular Repair, Reducing the Need for Repeat Surgical Procedures and Improving Patient Outcomes Cambridge, Mass. , March 1, 2011 — Pervasis Therapeutics, Inc. announced today that the European Commission (EC) has granted Orphan Drug Designation for Vascugel ® for the prevention of hemodialysis vascular access failure in patients with end stage renal disease (ESRD).The designation follows a positive opinion from The Committee for Orphan Medicinal Products (COMP) within the European Medicines Agency (EMA) earlier this year. Vascugel is a novel endothelial cell-based therapy that aims to regulate the body’s healing response following surgical interventions to create vascular access which are necessary for ESRD patients undergoing hemodialysis.By p romoting and enhancing vascular repair, Vascugel reduces the need for repeat surgical interventions and improves overall patient outcomes. ESRD is an advanced and irreversible condition treated mainly by hemodialysis or kidney transplantation. It is estimated that more than 250,000 ESRD patients in the EU receive hemodialysis, a blood purification therapy designed to replace critical kidney functions – such as filtering waste.Orphan Drug Designation by the EC provides regulatory and financial incentives for companies to develop and market therapies that treat a life-threatening or chronically debilitating condition affecting no more than five in 10,000 persons in the European Union (EU). In addition to a 10year period of marketing exclusivity in the EU after product approval, Orphan Drug Designation provides companies with scientific advice and regulatory assistance from the EMA during the product development phase, direct access to centralized marketing authorization, as wel l as reductions in certain fees. We are committed to bringing Vascugel to patients with end stage renal disease who currently must endure serious complications and repeat surgical procedures so they can continue to receive life-saving hemodialysis treatment,† Frederic Chereau, president and chief executive officer of Pervasis. â€Å"Receiving Orphan Drug Designation in the EU is an important step, as it will help to advance the development process, and enhance our ability to deliver our novel cellbased therapeutic approach to address this significant unmet medical need. Vascugel has demonstrated proof of concept in two Phase 2 clinical trials involving patients with ESRD who require a permanent arteriovenous (AV) access in order to undergo hemodialysis. In these trials, Vascugel exhibited an excellent safety profile, and encouraging efficacy trends were observed, including improved duration of patency (or unimpeded blood flow) and a delay in time to first intervention as comp ared to placebo. In 2009, Pervasis received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for Vascugel in patients with ESRD. Pervasis announced last month that the FDA had granted Fast Track review status for Vascugel. Last year, Pervasis reached an agreement with the FDA for a Phase 3 clinical trial of Vascugel under the Agency’s Special Protocol Assessment (SPA) procedure, whereby FDA formalized its agreement that the design of the Phase 3 trial was acceptable to support a regulatory submission seeking new drug approval.Failure of Hemodialysis Access Points Leads to Poor Outcomes During hemodialysis, blood is removed from the body, filtered through a dialyzer, or artificial kidney, and then returned to the body. Patients must undergo a surgical intervention to create a vascular access that enables blood to flow from the body to the dialyzer and back to the body. AV fistulae (created by directly joining an artery and vein) and AV grafts (created u sing a synthetic tube to join an artery and vein) are the two primary types of hemodialysis access.Due to an inflammatory cascade triggered by surgical intervention, the vascular access often has difficulty healing, and quickly become unusable or clot rapidly, prompting the need for additional, recurring surgeries to create a new access which can lead to multiple complications. Up to 60 percent of all arteriovenous (AV) grafts require re-intervention after one year. 1, 2 AV access failure is the most common reason for hospitalization among hemodialysis patients and can lead to anemia, infection, weight loss, jaundice, prolonged bleeding, and other serious complications. Vascugel ® – Combating Inflammation and Promoting Healing Pervasis’ novel approach to cell therapy uses adult-differentiated allogeneic endothelial cells (donor endothelial cells with a highly targeted biologic function) embedded in a polymer matrix to enhance the body’s natural healing respons e. The endothelium is the thin layer of cells that lines the interior surface of blood vessels in the body. Endothelial cells are critical to tissue repair and health, and have a well-understood role in regulating many of the body’s healing processes, including those associated with vascular repair.Vascugel, which utilizes Pervasis’ patented endothelial cell-based platform, is placed on the outside of the blood vessel at the AV access site during the surgical intervention to create the access. The endothelial formulation in Vascugel secrete several factors that combat inflammation and promote proper vascular healing, reducing thrombosis (or clotting) and the formation of intimal hyperplasia, or a thickening of the blood vessel wall in response to injury. After approximately four to eight weeks, Vascugel is safely resorbed by the body.Pervasis’ other areas of clinical investigation include improving outcomes in patients with peripheral artery disease (PAD) follow ing surgical procedures such as percutaneous transluminal angioplasties (PTAs) with stenting, the failures of which result in serious complications and a significant increase in medical costs. Earlier this year, Pervasis announced it has also embarked on an oncology development program using its proprietary endothelial cellbased platform to prevent solid tumor growth, cancer recurrence and metastatic disease. About Pervasis Dixon et al.DAC Study Group. Effect of dipyridamole plus aspirin on hemodialysis graft patency. N Engl J Med. 2009; 360: 2191-2201. 2 Hayashi et al. Vascular access for hemodialysis. Nat Clin Pract Nephrol 2006; 2: 504-513 3 Castner D. Recommendations for tracking arteriovenous access complications using a charting-by-exception model. Anna Journal, 1998; 25(4): 393-396. 1 Pervasis Inc. is a clinical stage company that is developing groundbreaking endothelial cellbased therapies designed to regulate the body’s natural healing and repair processes in various critical therapeutic areas.The company has initially focused on developing therapies to improve the outcomes of common vascular interventions, such as arteriovenous access, angioplasties, stent placements, and peripheral and coronary bypass grafts – the failure of which result in serious complications and a significant increase in medical costs. The company’s lead program, Vascugel ®, has demonstrated proof of concept and safety in two Phase 2 clinical trials.Pervasis is also applying its endothelial cell-based platform technology to develop an oncology therapy focused on preventing solid tumor growth, cancer recurrence and metastatic disease, as well as products for inflammatory disease and orthopedic injury. Pervasis is a privately held company with funding from Flagship Ventures, Polaris Venture Partners, Highland Capital Partners and the Richter Family Fund. For more information, please visit www. pervasistx. com. This news release contains certain forward-looki ng statements that involve risks and uncertainties.Such statements are only predictions and the company's actual results may differ materially from those anticipated in these forward-looking statements. Factors that may cause such differences include the timing of clinical trials, the risk that products that appeared promising in early research and clinical trials do not demonstrate safety or efficacy in clinical trials and the risk that the company will not obtain approval to market its products. Company Contact: Margaret O’Toole Pervasis Therapeutics, Inc. 617-871-1201 [email  protected] com Media Contact: Liz Falcone Feinstein Kean Healthcare 617-256-6622 liz. [email  protected] com

Dallas Architecture A Quick Tour of the Big D